Research different options to find the right pediatrician
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Check credentials and licensing
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What to consider when choosing the right tech stack?
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Look for experience in treating your child's age
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Consider location and availability
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Periodical Summary
In a small placebo-controlled study of 24 weeks, patients with preserved EF heart failure were placed on dapagliflozin/Faxiga 10 mg a day. At the end of the study, patients taking dapagliflozin had a lower pulmonary capillary wedge pressure at rest and with exercise. They also lost weight and had reduced plasma volume.
Dr. Max's Comment
SGLT2 inhibitors are now considered first line therapy for CHF. In previous studies, they have been shown to reduce hospitalizations due to CHF and cardiac mortality. There have been multiple proposed mechanisms of action. It appears reduced PCWP is one of them. SGLT2 should be used with caution in patients with chronic kidney disease. Otherwise, they have earned their place among the big four-beta blockers, ACE inhibitors, ARB’s and diuretics. For chronic, stable CHF, I like spironolactone for mild edema, but with the caveat that potassium levels should be closely followed and…don’t forget our tried-and-true friend, digoxin. For patients with CKD, digoxin levels are a must.
